Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung
نویسندگان
چکیده
منابع مشابه
Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung
BACKGROUND The histopathologic distinction between typical carcinoid (TC) and atypical carcinoid (AC) of the lung is based largely on mitotic index. Ki-67 may aid in separation of these tumors, as well as the distinction from large cell neuroendocrine carcinoma (LCNEC). METHODS We identified 55 surgically resected primary neuroendocrine lung tumors (39 TC, 7 AC, 9 LCNEC) based on mitotic rate...
متن کاملCelecoxib decreases Ki-67 proliferative index in active smokers.
PURPOSE This study evaluated the feasibility of cyclooxygenase-2 (COX-2) inhibition for lung cancer chemoprevention. We hypothesized that treatment with oral Celecoxib, a selective COX-2 inhibitor, would favorably alter the biomarkers of lung cancer risk as measured by the Ki-67 proliferative labeling index (Ki-67 LI). EXPERIMENTAL DESIGN Twenty active heavy smokers were enrolled into a pilot...
متن کاملMdm2 and p53 expressions and Ki-67 proliferative index in fibrohistiocytic tumors
Objective: Various genetic alterations including inactivation of tumor suppressor genes and activation of oncogenes, are described in different types of neoplasms as well as soft-tissue tumors. The purpose of the present study is to evaluate the expressions of mdm2 and p53, and Ki-67 proliferative activity and to investigate their interrelations with the clinicopathologic parameters in fibrohis...
متن کاملProliferative activity in human breast cancer: Ki-67 automated evaluation and the influence of different Ki-67 equivalent antibodies
BACKGROUND Ki67 labeling index (Ki67 LI), the percentage Ki67 immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it is extremely important to standardize its evaluation. AIM To test the efficacy of computer assisted image analysis (CAIA) applied to completely digitized slides and to assess its feasibility in routine practice and ...
متن کاملChromogranin A, Ki-67 index and IGF-related genes in patients with neuroendocrine tumors
UNLABELLED Chromogranin A (CgA) and the Ki-67 proliferation index are considered as important biochemical and pathological markers for clinical behaviour of gastroenteropancreatic neuroendocrine tumors (GEP NETs), respectively. The IGF system has been suggested as an important regulator of GEP NET proliferation and differentiation. A possible relationship between serum CgA (sCgA), Ki-67 prolife...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diagnostic Pathology
سال: 2014
ISSN: 1746-1596
DOI: 10.1186/s13000-014-0174-z